Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model.
Identifieur interne : 000672 ( Main/Exploration ); précédent : 000671; suivant : 000673Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model.
Auteurs : Ensiyeh Seyedrezazadeh [Iran] ; Saeed Kolahian ; Amir-Ali Shahbazfar ; Khalil Ansarin ; Masoud Pour Moghaddam ; Masoud Sakhinia ; Ebrahim Sakhinia ; Mohammadreza VafaSource :
- Phytotherapy research : PTR [ 1099-1573 ] ; 2015.
English descriptors
- KwdEn :
- Airway Remodeling (drug effects), Animals, Asthma (drug therapy), Asthma (pathology), Beverages, Bronchoalveolar Lavage Fluid (cytology), Citrus paradisi (chemistry), Citrus sinensis (chemistry), Disease Models, Animal, Eosinophils (cytology), Flavanones (pharmacology), Fruit (chemistry), Hesperidin (pharmacology), Inflammation (drug therapy), Lung (pathology), Macrophages (cytology), Male, Mice, Mice, Inbred BALB C.
- MESH :
- chemical , pharmacology : Flavanones, Hesperidin.
- chemistry : Citrus paradisi, Citrus sinensis, Fruit.
- cytology : Bronchoalveolar Lavage Fluid, Eosinophils, Macrophages.
- drug effects : Airway Remodeling.
- drug therapy : Asthma, Inflammation.
- pathology : Asthma, Lung.
- Animals, Beverages, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C.
Abstract
We investigated whether flavanones, hesperetin-naringenin, orange, and grapefruit juices reduce airway inflammation and remodeling in murine chronic asthma model. To establish chronic asthma, mice received house dust mite (HDM) for 3 days in 2 weeks, followed by twice per week for 4 weeks. Concurrently, during the last 4 weeks, mice received hesperetin plus naringenin (HN), orange plus grapefruit juice (OGJ), orange juice (OJ), or grapefruit juice (GJ); whereas the asthmatic control (AC) group and non-asthmatic control (NC) group consumed water ad libitum. In histopathological examination, no goblet cells metaplasia was observed in the HN, OJ, and GJ groups; also, intra-alveolar macrophages decreased compared with those of the AC group. Hesperetin plus naringenin significantly decreased subepithelial fibrosis, smooth muscle hypertrophy in airways, and lung atelectasis compared with the AC group. Also, there was a reduction of subepithelial fibrosis in airways in OJ and GJ groups compared with AC group, but it was not noticed in OGJ group. In bronchoalveolar lavage fluid, macrophages numbers decreased in OJ and OGJ groups, whereas eosinophil numbers were increased in OJ group compared with NC group. Our finding revealed that hesperetin plus naringenin ameliorate airway structural remodeling more than orange juice and grapefruit juice in murine model of HDM-induced asthma.
DOI: 10.1002/ptr.5292
PubMed: 25640915
Affiliations:
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Le document en format XML
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<author><name sortKey="Shahbazfar, Amir Ali" sort="Shahbazfar, Amir Ali" uniqKey="Shahbazfar A" first="Amir-Ali" last="Shahbazfar">Amir-Ali Shahbazfar</name>
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<author><name sortKey="Pour Moghaddam, Masoud" sort="Pour Moghaddam, Masoud" uniqKey="Pour Moghaddam M" first="Masoud" last="Pour Moghaddam">Masoud Pour Moghaddam</name>
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<term>Beverages</term>
<term>Bronchoalveolar Lavage Fluid (cytology)</term>
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<front><div type="abstract" xml:lang="en">We investigated whether flavanones, hesperetin-naringenin, orange, and grapefruit juices reduce airway inflammation and remodeling in murine chronic asthma model. To establish chronic asthma, mice received house dust mite (HDM) for 3 days in 2 weeks, followed by twice per week for 4 weeks. Concurrently, during the last 4 weeks, mice received hesperetin plus naringenin (HN), orange plus grapefruit juice (OGJ), orange juice (OJ), or grapefruit juice (GJ); whereas the asthmatic control (AC) group and non-asthmatic control (NC) group consumed water ad libitum. In histopathological examination, no goblet cells metaplasia was observed in the HN, OJ, and GJ groups; also, intra-alveolar macrophages decreased compared with those of the AC group. Hesperetin plus naringenin significantly decreased subepithelial fibrosis, smooth muscle hypertrophy in airways, and lung atelectasis compared with the AC group. Also, there was a reduction of subepithelial fibrosis in airways in OJ and GJ groups compared with AC group, but it was not noticed in OGJ group. In bronchoalveolar lavage fluid, macrophages numbers decreased in OJ and OGJ groups, whereas eosinophil numbers were increased in OJ group compared with NC group. Our finding revealed that hesperetin plus naringenin ameliorate airway structural remodeling more than orange juice and grapefruit juice in murine model of HDM-induced asthma.</div>
</front>
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<tree><noCountry><name sortKey="Ansarin, Khalil" sort="Ansarin, Khalil" uniqKey="Ansarin K" first="Khalil" last="Ansarin">Khalil Ansarin</name>
<name sortKey="Kolahian, Saeed" sort="Kolahian, Saeed" uniqKey="Kolahian S" first="Saeed" last="Kolahian">Saeed Kolahian</name>
<name sortKey="Pour Moghaddam, Masoud" sort="Pour Moghaddam, Masoud" uniqKey="Pour Moghaddam M" first="Masoud" last="Pour Moghaddam">Masoud Pour Moghaddam</name>
<name sortKey="Sakhinia, Ebrahim" sort="Sakhinia, Ebrahim" uniqKey="Sakhinia E" first="Ebrahim" last="Sakhinia">Ebrahim Sakhinia</name>
<name sortKey="Sakhinia, Masoud" sort="Sakhinia, Masoud" uniqKey="Sakhinia M" first="Masoud" last="Sakhinia">Masoud Sakhinia</name>
<name sortKey="Shahbazfar, Amir Ali" sort="Shahbazfar, Amir Ali" uniqKey="Shahbazfar A" first="Amir-Ali" last="Shahbazfar">Amir-Ali Shahbazfar</name>
<name sortKey="Vafa, Mohammadreza" sort="Vafa, Mohammadreza" uniqKey="Vafa M" first="Mohammadreza" last="Vafa">Mohammadreza Vafa</name>
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<country name="Iran"><noRegion><name sortKey="Seyedrezazadeh, Ensiyeh" sort="Seyedrezazadeh, Ensiyeh" uniqKey="Seyedrezazadeh E" first="Ensiyeh" last="Seyedrezazadeh">Ensiyeh Seyedrezazadeh</name>
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